Hyperthermia Cancer Theraphy

The life-saving potential of tumor heating has long been proven, backed by extensive scientific research and hundreds of randomized trials, including over 40 phase III studies, demonstrating its potent efficacy in cancer treatment. Yet, despite these undeniable benefits, traditional hyperthermia equipment has faced significant barriers—bulky, cumbersome machines, prolonged procedures, exorbitant costs, and the persistent challenge of achieving optimal tumor temperatures above 43°C (110°F) without damaging the skin.

What is Hyperthermia (HT) Cancer Therapy?

Hyperthermia Deep Tissue Heating System: a revolutionary breakthrough designed to overcome these limitations and transform cancer care. Inside Health utilizes cutting-edge technology to deliver high-frequency electromagnetic energy deep into biological tissues through advanced applicators. This energy induces molecular friction, precisely heating tumors to therapeutic temperatures between 42°C and 46°C (108°F and 115°F). This process destroys cancer cells while preserving the integrity of healthy surrounding tissues. By making tumor heating safer, more efficient, and easier to administer, the Hyperthermia unit redefines what’s possible in cancer therapy. It offers hope to countless patients and positions itself as a game- changer in the ongoing fight against cancer. The future of hyperthermia is here, and with it, the promise of more effective and accessible treatment for cancer patients everywhere.

Overview

Minimal risk of toxicity – Out of over 100,000 treatments administered, the only reported adverse reaction was mild skin erythema in a small number of cases

Problems Addressed

Mechanisms of Action for Cancer

Increased blood flow delivers more drugs in and around the tumor
Hyperthermia inhibits the repair of DNA damage caused by radiation and chemotherapy [2] Increases cytotoxicity of chemotherapy Protein Denaturation—
Heating causes cellular proteins to denature, impairing cellular function and eventually leading to cell death
Membrane Damage - Heat can disrupt the integrity of the cellular membrane, causing leakage of vital cellular contents and increasing cell permeability
Blood Vessel Permeability - Hyperthermia increases the permeability of blood vessels in tumors, making it easier for anticancer agents to penetrate and accumulate in the tumor tissue
Directly kills cancer stem-like cells at higher temperatures
Damages tumor vasculature at higher temperatures
Immune Activation: Hyperthermia can stimulate the immune system by releasing damage-associated molecular patterns (DAMPs) from dying tumor cells, enhancing immune cells’ recognition of cancer cells
Increased Antigen Presentation: Heat shock can increase the expression of antigens on the surface of cancer cells, making them more recognizable to immune cells like cytotoxic T lymphocytes
Drug-free pain mitigation through multiple mechanisms of action

The Benefits of Adding Hyperthermia to Chemotherapy

Adding hyperthermia to chemotherapy offers several significant benefits, enhancing the overall effectiveness of cancer treatment. These benefits include:

1. Increased Sensitivity of Cancer Cells: Hyperthermia makes cancer cells more sensitive to chemotherapy by disrupting their repair mechanisms and weakening their defenses, leading to increased cell death.

2. Enhanced Drug Delivery: The heat from hyperthermia improves blood flow in the tumor, allowing better delivery of chemotherapy drugs to the cancer cells and increasing their local concentration.

3. Targeted Tumor Destruction: Hyperthermia primarily affects cancer cells, which are more heat-sensitive than normal cells. Leading to more targeted tumor destruction without damaging collateral tissues.

4. Reduction in Drug Resistance: Hyperthermia can overcome some forms of chemotherapy resistance in cancer cells, making previously resistant tumors more responsive to treatment.

5. Stimulation of the Immune System: Hyperthermia can enhance the immune system’s response by releasing heat shock proteins and tumor antigens, improving immune recognition and attacking cancer cells.

6. Synergistic Effects: The combination of hyperthermia and chemotherapy has a synergistic effect, leading to better outcomes regarding tumor shrinkage and survival rates.